Major ECG abnormalities associated with increased CVD risk in type 1 diabetes

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  • ECG screening could be used in patients with type 1 diabetes (T1D) to identify those at risk for cardiovascular disease (CVD).

Why this matters

  • CVD is leading death cause in T1D, but not all patients are at equal risk.

Study design

  • Data analysis for 1306 patients with T1D from Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.
  • ECG abnormalities defined as major, minor, or no abnormality.
  • CVD events defined as first occurrence of myocardial infarction, stroke, confirmed angina, coronary artery revascularization, congestive heart failure, or any CVD death.
  • Funding: NIH, with supplies from pharmaceutical companies.

Key results

  • During median 19 y follow-up, 11.9% (n=155) developed CVD events (46.8/10,000 person-y; 95% nonfatal).
  • After fu...