MCRC: nomogram predicts early mortality on initial treatment

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Takeaway

  • Validated clinical nomogram has been developed that quantifies the risk for early death in patients during initial treatment of metastatic colorectal cancer (mCRC) and may be used for treatment stratification.

Why this matters

  • Prognostic factors associated with early mortality in mCRC remain poorly understood.

Key results

  • Mortality rates were 1.4%, 3.4%, and 5.5% at 30, 60, and 90 d, respectively.
  • Various baseline factors were associated with increased probability of early mortality, including advanced age, lower BMI, poorer performance status, increased number of metastatic sites, BRAF mutant status, and several laboratory parameters.
  • Multivariable model for 90-d mortality was constructed that demonstrated strong internal discrimination (C-index, 0.772) and good calibration across ri...