Metastatic melanoma: Newer TKIs and immune checkpoint inhibitors lead the way in survival

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  • In an explorative analysis of different studies in metastatic melanoma, the optimal survival outcomes were observed with combination BRAF and MEK inhibition, or immune checkpoint inhibition.

Study Design

  • Explorative analysis comparing survival data from different clinical trials of current interest in metastatic melanoma.
  • 35 Kaplan-Meier curves (PFS, OS, or both) from 17 Phase I-III clinical trials were included.

Key Results

  • Average 12-month OS in 1L: BRAFi + MEKi: 74.5%; PD-1 inhibition: 71.9%.


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