Mild hypercortisolism persists despite Cushing’s treatment

Miriam E. Tucker | Clinical Summary | 10 May 2023

Findings suggest normalisation of urinary free cortisol should not be the only biochemical target of cortisol-lowering drugs in Cushing’s disease.

Source

Journal of Clinical Endocrinology and Metabolism .

Takeaway

A significant subset of patients with Cushing’s disease (CD) treated with cortisol-lowering drugs exhibited persistent mild hypercortisolism despite consistently normalised urinary free cortisol (UFC).

Why this matters

Pituitary tumor excision surgery is unsuccessful in 15%-25% of patients with CD, and recurrence...

Mild hypercortisolism persists despite Cushing’s treatment

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