- High throughput imaging can identify patients with high risk non-alcoholic steatohepatitis (NASH) + fibrosis.
Why this matters
- Used as a screening tool, this imaging technique can identify at-risk patients from the general population.
- In the unselected population sample, 20.7% had steatosis (5% proton density fat fraction [PDFF]), in agreement with UK population estimates.
- In the non-alcoholic fatty liver disease (NAFLD) cohort, 74.5% had PDFF 5% (mean PDFF 12.64%).
- The mean liver inflammation and fibrosis (LIF) score in the high-risk NASH cohort was 2.70
- A LIF score 2 is associated with a higher likelihood of high-risk NAFLD and liver-related clinical outcomes.
- In the unselected group, LIF ranged from 0 to 3.4 with a mean of 0.96.