Multiparametric MRI can identify patients at risk of NAFLD | EASL

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  • High throughput imaging can identify patients with high risk non-alcoholic steatohepatitis (NASH) + fibrosis. 

Why this matters

  • Used as a screening tool, this imaging technique can identify at-risk patients from the general population. 

Key results

  • In the unselected population sample, 20.7% had steatosis (5% proton density fat fraction [PDFF]), in agreement with UK population estimates.
  • In the non-alcoholic fatty liver disease (NAFLD) cohort, 74.5% had PDFF 5% (mean PDFF 12.64%).
  • The mean liver inflammation and fibrosis (LIF) score in the high-risk NASH cohort was 2.70
  • A LIF score 2 is associated with a higher likelihood of high-risk NAFLD and liver-related clinical outcomes.
  • In the unselected group, LIF ranged from 0 to 3.4 with a mean of 0.96.
  • In...