Myelofibrosis: meeting the needs of the ruxolinitib-resistant/intolerant?
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- In a phase 2 study, the Janus kinase-2 (JAK2)-selective inhibitor fedratinib delivered meaningful clinical benefit to ruxolitinib (Jakafi)-resistant/intolerant patients with myelofibrosis.
- Further study is required to elucidate toxicities.
Why this matters
- 50% of patients discontinue ruxolitinib within 3-5 y.
- An unmet need remains for patients with myelofibrosis who are resistant to or unable to tolerate ruxolitinib.
- Phase 2 study to investigate the safety and efficacy of fedratinib in ruxolitinib-resistant/intolerant patients with intermediate/high-risk myelofibrosis.
- All patients had palpable splenomegaly.
- 97 patients were enrolled; 83 were assessable for efficacy.
- Funding: Sanofi.
- 55% of patients achieved ≥35% reduction from baseline spleen volume at the end of Cycle 6, including 53% of...