Neonatal HIV: variability seen in virologic response to early ART | CROI
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Variability was seen in virologic response to early antiretroviral therapy (ART) among HIV-infected infants identified at birth.
Why this matters
ART initiated soon after primary infection is thought to influence seeding of the viral reservoir, with beneficial effects for virologic control.
Of 100 HIV-infected infants identified, 68 were enrolled in a clinical trial tracking their response to ART.
Analyzed were infants who started ART 0-15 days and were alive and still in follow-up at six months.
Eleven percent of treated infants were found to have persistently high HIV RNA levels, 35% a declining trajectory that has not yet reached lower detection limit (LDL), and 54% have declined to LDL or target n...