Nephrotoxicity of vemurafenib and babrafenib, particularly in male patients with BRAF mutation positive melanoma

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The BRAF inhibitors vemurafenib and dabrafenib have shown significant improvement in patient survival compared with standard therapy in BRAF V600-mutant metastatic melanoma. Results suggest vemurafenib seems to be more nephrotoxic than dabrafenib and renal toxicity seems to be more prevalent am...