Neurodegenerative and Neuromuscular Disorder Vitals for June 2017

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We screened 794 studies on Neurodegenerative and Neuromuscular Disorder this month. These are the most important.

Minocycline and MS risk: antibiotic reduces conversion from clinically isolated syndrome

Source: N Engl J Med

  • Minocycline appears to reduce the risk for conversion of clinically isolated syndrome to multiple sclerosis (MS) in the short term.
  • Minocycline has shown some benefit in patients with established MS and is generally safe.


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Huntington's disease: plasma levels of NfL are linked to prognosis

Source: Lancet Neurol

  • Among HTT mutation carriers, plasma neurofilament light protein (NfL) correlated with changes in cognitive function, motor function, and brain volume.
  • There is no clinical blood test for estimating Huntington's disease onset and prognosis.

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PD: extended-release amantadine useful for levodopa-induced dyskinesia

Source: JAMA Neurol