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New way to predict autoimmune toxicity from immune checkpoint inhibitor treatment for cancer

Miriam Davis   |   Clinical Summary   |   24 January 2023
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Takeaway

  • Immune signatures in blood shortly after starting immune checkpoint inhibitor (ICI) therapy predict which cancer patients proceed to develop autoimmune toxicity.
  • The signatures consist of expanded T cell subsets that express Ki-67, a well-known marker of cell proliferation, and increases in several proteins involved in the interferon-gamma signalling pathway...

          

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