Nonmelanoma skin cancer increases risk for melanoma and other primary malignanices

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Takeaway
  • These findings corroborate previous data showing nonmelanoma skin cancer (NMSC) is associated with increased risk for melanoma and other noncutaneous malignancies.
Study design
  • The Women's Health Initiative (WHI) Observational Study OS (N=93,676) and Clinical Trial (CT; N=68,132) were composed of postmenopausal women aged 50-79 y.
  • Detailed demographic and cancer risk factors were collected at baseline (1993-1998), and all cancer diagnoses through August 2014 were reported by annual questionnaire.
Key results
  • NMSC history at baseline was associated with a higher risk for any cancer diagnosis (HR, 1.20; 95% CI, 1.20-1.30), breast cancer (HR, 1.21; 95% CI, 1.13-1.34), lung cancer (HR, 1.26; 95% CI, 1.12-1.42), melanoma (HR, 2.42; 95% CI, 2.15-2.73), non-Hodgkin lymphoma (NHL; HR, 1.40; 95% CI, 1.18-1.65), and leukemia (HR, 1.28; 95% CI, 1.02-1.60).
  • The risk for...