Omega-3 polyunsaturated fatty acids as a supplement to migraine prophylaxis

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  • Supplementation of omega-3 polyunsaturated fatty acids (OPFAω-3) may increase prophylactic effects of amitriptyline in patients with migraine.

Why this matters

  • For patients who are not getting full benefits from amitriptyline, supplementation with OPFAω-3 may help.

Key results

  • Nine patients dropped out because of adverse effects from amitriptyline.
  • Patients who took OPFAω-3 saw an 80.0% reduction in the number of headache days in 66.7% of patients, whereas 33.3% of placebo patients saw the same level reduction (P=.036...