Oral cancer: HPV/p53 mutation combination strongly associated with reduced survival

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Takeaway

  • Combined HPV infection and mutated p53 is associated with reduced overall survival of advanced oral squamous cell carcinoma (OSCC) patients.

Key results

  • The combination of HPV infection and p53 mutation was significantly associated with reduced overall survival (33.3% vs. 91%, p=.000).
  • HPV infection alone was not significantly associated with overall survival (71.3% vs. 64.8%, p=.78).
  • HPV infection incidence decreased with increasing p53 expression (p=0.005).
  • The HPV-positive, p53-mutated combination increased with increasing p53 expression (p...