Oral cancer outcomes associated with proteasomal activator PA28γ

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Takeaway

  • High expression of the proteasomal activator PA28γ is associated with reduced survival of oral squamous cell carcinoma (OSCC) patients.

Key results

  • In three separate cohorts, patients with high tumor expression of PA28γ had worse overall survival compared with low-expressing patients (p<.001, p<.001, and p=.003, respectively).
  • Expression of PA28γ was also significantly associated with disease-free survival (p<.005 for all three cohorts).
  • Addition of PA28γ to traditional clinical factors significantly improved prediction of all-cause mortality (p=.016...