Oral cancer treatment response and prognosis associated with osteopontin expression

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  • Low expression of the cytokine osteopontin (OPN) is associated with better response to chemotherapy and improved overall survival of oral squamous cell carcinoma (OSCC) patients.

Key results

  • Patient response to chemotherapy was significantly associated with low tumor expression of OPN (p=.002).
  • Patients with low tumor expression of OPN had significantly better overall survival compared with high-expressing patients (P<.001).
  • Negative OPN expression was an independent predictor of improved overall survival in multivariate analysis (p=.028).

Study design

  • Biopsy samples from 1...