Oropharyngeal cancer: high T cell count correlates with improved prognosis of HPV+ disease

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Takeaway

  • A high number of tumor-infiltrating T cells is associated with improved survival of oropharyngeal squamous cell carcinoma (OPSCC) patients with a low number of IL-17+ non-T cells or human papillomavirus-positive (HPV+) disease.

Key results

  • The number of T cells was significantly higher in HPV+ disease than HPV- disease (p<.0001).
  • A high number of T cells was significantly associated with improved disease-free survival (DFS) in HPV+ patients (p=.008).
  • A high number of T cells was significantly associated with improved DFS in patients with low number of IL-17+ non-T cells (p=.012)....