Oropharyngeal cancer: HPV+ patients have reduced risk for second primary neoplasm

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Takeaway

  • Human papillomavirus (HPV)-positive status is associated with reduced risk for second primary neoplasm (SPN) in patients with oropharyngeal cancer (OPC).

Why this matters

  • This study confirms prior research reporting decreased incidence of SPN in patients with HPV-positive OPC.

Key results

  • HPV-positive patients had higher 5-y and 10-y SPN-free survival compared with HPV-negative patients (89.0% vs 57.0%; P<.001 and 78.5% vs 35.2%; P<.001, respectively).
  • In subgroup analysis of tobacco/alcohol-related SPNs, HPV-positive patients also had higher 5-y and 10-y SPN-free survival (97.6% vs 62.0%; P<.001 and 97.6% vs 42.2%; P<.001, respectively).
  • HPV status was associated with SPN risk in multivariate analysis (HR, 3.7; P<.001).

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