OSCC: advanced pathology associated with loss of tight junction protein

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Takeaway

  • Negative expression of the tight junction protein claudin-7 is associated with advanced clinicopathologic features of oral squamous cell carcinoma (OSCC).

Key results

  • Loss of claudin-7 was significantly associated with high pathologic grade (P=.027), advanced TNM staging (P=.00), large tumor size (P=.014), microscopic perineural invasion (P=.01), microscopic vascular invasion (P=.031), and regional lymph node involvement (P=.001).
  • High claudin-7 expression was significantly associated with improved survival (P=.012)....