OSCC: ASC expression predicts prognosis

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Takeaway

  • Elevated expression of apoptosis-associated speck-like protein containing a CARD (ASC) is associated with advanced pathology and poor survival outcomes of oral cavity squamous cell carcinoma (OSCC).

Key results

  • High ASC expression was significantly associated with tumor stage (P=.001), node stage (P<.001), overall stage (P<.001), extracapsular spread (P<.001), perineural invasion (P=.004), and tumor depth (P<.001).
  • High ASC expression was significantly associated with decreased overall survival (HR, 2.510; 95% CI, 1.116-5.646; P=.026), disease-specific survival (HR, 2.935; 95% CI, 1.251-6.886; P=.013), and disease-free survival (HR, 2.153; 95% CI, 1.026-4.519; P=.042) in multivariate analysis.

Study design

  • Clinical specimens for 111 patients with OSCC were analyzed by immunohistochemistr...