OSCC: increasing usage of low-efficacy nonsurgical therapy

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  • Rates of nonsurgical therapy increased 8% from 1988 to 2008 in patients with resectable advanced-stage oral cavity squamous cell carcinoma (OSCC).

Key results

  • Nonsurgical therapy was associated with significantly reduced DFS (63 vs 115 mo; P<.001) and OS (35 vs 71 mo; P<.001) compared with surgical therapy.
  • Nonsurgical therapy use was associated with hard palate tumors (P<.001), single patients (P=.028), widowed patients (P<.001), black patients (P<.001), T3 stage (P<.001), T4 stage (P<.001), and N3 stage (P<.001).
  • Nonsurgical therapy rates increased from 12% to 20% between 1988-1991 and 2005-2008 (P<.05)

Study design

  • 5856 patients with resectable advanced-stage oral cavity SCC from the Surveillance, Epidemiology, and End Results database were analyzed for rates of surgical vs nonsurgical therapy and associated survival outcomes.
  • Funding: Source of funding not disclosed.