OSCC: nodal involvement predicts survival

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Takeaway

  • The level of nodal involvement is associated with the survival of patients with advanced oral squamous cell carcinoma (OSCC).

Key results

  • Extensive clinical nodal (cN) involvement was associated with decreased OS and DFS in univariate analysis (HR, 3.27; 95% CI, 1.50-7.13; P=.001 and HR, 2.81; 95% CI, 1.36-5.81; P=.003, respectively).
  • Extensive pathological nodal (pN) involvement was associated with decreased OS and DFS in multivariate analysis (HR, 4.71; 95% CI, 1.85-11.97; P=.001 and HR, 6.28; 95% CI, 3.02-13.06; P<.001, respectively).
  • Multiple pN was associated with decreased OS in multivariate analysis (HR, 2.59; 95% CI, 1.10-6.09; P=.029).

Study design

  • 105 patients with clinical stage III-IV OSCC who received preoperative chemoradiotherapy w...