OSCC prognosis linked to urinary PGE-M levels

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Takeaway

  • Urinary levels of PGE-M, a metabolite of cyclooxygenase-2-derived prostaglandin E2 (PGE2), are associated with survival of oral squamous cell carcinoma (OSCC) patients.

Key results

  • OSCC patients had significantly increased PGE-M levels compared with controls (48.7 vs 24.5 ng/mg, P<.001).
  • OSCC patients who progressed after treatment had significantly higher PGE-M compared with patients who remained progression free (64.7 vs 33.8 ng/mg, P<.001).
  • High baseline PGE-M was significantly associated with reduced disease-specific survival (...