OSCC: response to preoperative radiotherapy is the best prognostic factor

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Takeaway

  • Tumor response to preoperative radiotherapy, neutrophil level, and C-reactive protein (CRP) level are associated with survival of patients with oral squamous cell carcinoma (OSCC) after surgery.

Key results

  • Poor response to radiotherapy (regression grade 4; HR, 3.58; 95% CI, 2.14-5.98; P<.001), elevated neutrophil number (HR, 2.22; 95% CI, 1.18-4.18; P=.01), and elevated CRP level (HR, 1.74; 95% CI, 1.05-2.89; P=.03) were associated with reduced OS.
  • Regression grade was an independent predictor of OS in multivariate analysis (HR, 4.23; 95% CI, 2.26–7.75; P<.001).

Study design

  • 144 patients with stage III-IV OSCC who received preoperative radiotherapy were analyzed for factors associated with OS after radical surgery.
  • Funding: Source of fu...