Overexpression of basic fibroblast growth factoris a potential indicator of worse prognosis for patients with operable NSCLC and SCLC

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Takeaway

  • Basic fibroblast growth factor (bFGF) is known to stimulate angiogenesis, and overexpression is a potential indicator of worse prognosis for patients with operable non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC).

Study design

  • Meta-analysis of 22 studies (n = 2154),and endpoints were pooled hazard ratios (HR) for overall survival (OS).

Key results

  • Combined HR suggests that bFGF overexpression had an adverse impact on survival of patients with lung cancer(HR = 1.202,95%CI, 1.022-1.382).
  • Subgroup analysis showed that the combined HR evaluating bFGF expression on OS in operable NSCLC was 1.553 (95%CI, 1.120-1.986) and the combined HR in SCLC was 1.667 (95%CI, 1.035-2.299).
  • There was no significant ...