Panic disorder: relapse common, but less so with clonazepam than paroxetine
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After 6 y of follow-up, the relapse rate after discontinuation of treatment with clonazepam (Klonopin) and paroxetine (Paxil, Brisdelle, Pexeva) was 89.4%, but relapse rates were consistently lower in those who had been treated with clonazepam.
Why this matters
Long-term pharmacological treatment with clonazepam or paroxetine fails to adequately control panic disorder after the drug is discontinued.
85 patients who had been randomized to receive either clonazepam or paroxetine for 8 weeks in an open label trial. Those who achieved remission at 34 months had their medication discontinued and then were followed up out to 6 y after discontinuation.