Panic disorder: relapse common, but less so with clonazepam than paroxetine

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  • After 6 y of follow-up, the relapse rate after discontinuation of treatment with clonazepam (Klonopin) and paroxetine (Paxil, Brisdelle, Pexeva) was 89.4%, but relapse rates were consistently lower in those who had been treated with clonazepam.

Why this matters

  • Long-term pharmacological treatment with clonazepam or paroxetine fails to adequately control panic disorder after the drug is discontinued.

Study design

  • 85 patients who had been randomized to receive either clonazepam or paroxetine for 8 weeks in an open label trial. Those who achieved remission at 34 months had their medication discontinued and then were followed up out to 6 y after discontinuation.
  • Funding: Brazilian ...