Pneumonia-related ARDS: the significance of coinfection

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  • Coinfection with a virus and another pathogen is not unusual and is associated with higher hospital mortality.

Why this matters

  • The effect of causal pathogens on the outcomes of pneumonia-related acute respiratory distress syndrome (ARDS) should be addressed because most pathogens are potentially treatable.

Study design

  • Prospective, observational cohort study.
  • Adult patients with pneumonia-related ARDS receiving bronchoalveolar lavage (BAL) after negative tracheal aspirate or sputum culture.
  • All patients received empiric antimicrobials before BAL.
  • Funding: None.

Key results

  • 255 patients.
  • 55.7% were pathogen-positive, of whom 39.8% had bacterial, 62% had viral, and 57% had fungal pathogens.
  • Most common gram-negative and gram-positive bacteria were Pseudomonas aeruginosa and methicillin-resistant Staphylococ...