Poor oral health increases OPSCC risk, regardless of HPV status

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  • Poor oral health, including smoking, is associated with increased risk for both human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC).

Key results

  • Routine dental examination was associated with reduced risk for HPV-negative (OR, 0.52; 95% CI, 0.35-0.76; P<.001) and HPV-positive (OR, 0.55; 95% CI, 0.36-0.86; P=.009) OPSCC.
  • Smoking ≥10 pack-years was associated with increased risk for HPV-negative (OR, 4.26; 95% CI, 2.85-6.37; P<.001) and HPV-positive (OR, 1.62; 95% CI, 1.10-2.38; P=.014) OPSCC.
  • Tooth mobility was associated with increased risk for HPV-negative OPSCC (OR, 1.70; 95% CI, 1.18-2.43; P=.004), but not HPV-positive OPSCC (OR, 1.45; 95% CI, 0.95-2.20; P=.083).

Study design

  • 102 patients with HPV-positive OPSCC, 145 patients with HPV-negative OPSCC, and 1396 control patients were analyzed for asso...