Post-op Crohn's recurrence associated with specific changes in fecal microbiome | ECCO

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Takeaway

  • Specific bacterial genera are associated with disease recurrence after Crohn's disease resection.
  • Positive associations need to be investigated for a possible causative role, while negative associations (decreases within the orders Clostridiales and Lactobacillales) require investigation for a possible protective role. 

Why this matters

  • Crohn's disease usually recurs after “curative” resection; this may relate to specific microbial populations playing a pathogenic role. 

Key results

  • Diversity increased significantly after surgery (all patients, baseline versus 18 months (P=0.048).
  • At six months, diversity was significantly greater for patients who remained in remission compared to those with recurrence (P=0.04).
  • At 18 months, a similar trend was observed but the results were not significant (P=0.185).
  • Overall bacterial composition differed between recurrence and remission at 18 months (P=0.008), as well as over time (all patients and all samples: baseline, six, 12 and 18 months; P=0.001).
  • Nine genera (four from the or...