PPV23 vaccine is effective against pneumococcal disease in the elderly

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  • The 23-valent pnsumococcal polysaccharide vaccine (PPV23; Prevnar) is effective against invasive pneumococcal disease (IPD) and pneumoccal pneumonia in the elderly, according to a meta-analysis.
Why this matters
  • High rates of hospitalizations and mortality are observed in the 20-30% of cases of community-acquired pneumonia caused by pneumococcus.
Study design
  • 17 clinical trials, cohort studies and case-control studies met eligibility criteria after search of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews.
  • Risk of bias was assessed.
  • Random effects meta-analysis was conducted.
  • Funding: No external fun...