Pregnancy: risk for topiramate-related clefting higher with antiepileptic use

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Takeaway

  • Women receiving topiramate (Topamax) early in pregnancy for epilepsy vs other conditions were more likely to give birth to an infant with an oral cleft.

Why this matters

  • Influence of indication and dose on teratogenicity of topiramate is unclear.

Key results

  • Mater...