Prostate cancer: BRCA2 carriers respond to platinum-based chemotherapy

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Takeaway
  • In men with castration-resistant prostate cancer (PCa), breast cancer 2 (BRCA2) carriers showed an improved response to platinum-based chemotherapy compared with non-carriers.

Why this matters

  • BRCA2-associated breast and ovarian cancers are sensitive to platinum-based chemotherapy. 
  • It has been unknown whether BRCA2-associated PCa also responds favorably. 
  • Platinum agents have shown little benefit in the treatment of PCa, except for small cell PCa. 
  • The response rate observed in the present study is higher than that observed in previous studies of docetaxel-refractory castration-resistant PCa, including the cabazitaxel trial. 
  • The results suggest benefit in determining BRCA2 status and personalizing treatment with carboplatin for mutation carriers.

Study design

  • In this retrospective study, 141 patients with metastatic castration-resistant PCa received at ...