R/R MCL: new combo regimen shows promise in salvage patients

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Takeaway

  • Bortezomib (Velcade) + cyclophosphamide  (Cytoxan) + rituximab (Rituxan, BCR) is a new, efficacious, and well-tolerated salvage regimen for the treatment relapsed/refractory mantle cell lymphoma (R/R MCL).

Why this matters

  • Relapsed/refractory (R/R) MCL has poor prognosis and is associated with multiple genetic drivers necessitating therapeutic targeting of multiple pathways.

Study design

  • Phase 2 study to investigate the safety and efficacy of combination BCR in 21 patients with R/R MCL; median age: 66 y.
  • Funding: Millennium: The Takeda Oncology Company.

Key results

  • Median of 3 cycles received in 19 patients; among these, 74% ach...