Longer disease duration and lower total hip bone mineral density (BMD) predicted incident vertebral fracture in this small prospective study of women with systemic lupus erythematosus (SLE).
Why this matters
- Patients with SLE have an elevated risk for vertebral fracture, but the role played by BMD in this link is unclear.
- Treatment is available for corticosteroid-induced osteoporosis, so determining who is at highest risk is important.
- During 8 y, 35 (31.8%) patients developed 80 new vertebral fractures.
- Baseline differences between patients with vs without later fracture included:
— Lower hip BMD at total hip (P=.011).
— Longer disease duration (P=.005).
— Higher cumulative glucocorticoid dose (P=.037).
Longer disease duration and hip BMD emerged as independent risk factors in multivariate logistic analysis (P=.029 and P=.022, respectively).