Risk factors for vertebral fracture in lupus

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  • Longer disease duration and lower total hip bone mineral density (BMD) predicted incident vertebral fracture in this small prospective study of women with systemic lupus erythematosus (SLE).

Why this matters

  • Patients with SLE have an elevated risk for vertebral fracture, but the role played by BMD in this link is unclear.
  • Treatment is available for corticosteroid-induced osteoporosis, so determining who is at highest risk is important.

Key results

  • During 8 y, 35 (31.8%) patients developed 80 new vertebral fractures.
  • Baseline differences between patients with vs without later fracture included:

        — Lower hip BMD at total hip (P=.011).

        — Longer disease duration (P=.005).

        — Higher cumulative glucocorticoid dose (P=.037).

  • Longer disease duration and hip BMD emerged as independent risk factors in multivariate logistic analysis (P=.029 and P=.022, respectively).

Study ...