Scoring system predicts weight loss after gastric bypass
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A new scoring system based on adipose tissue fibrosis can identify patients with poor potential for weight loss after Roux-en-Y gastric bypass (RYGB).
Why this matters
Many, but not all, patients experience major, sustainable weight loss after bariatric surgery; the ability to predict poor responders would improve postoperative patient follow-up.
Researchers created a semiquantitative scoring system based on both perilobular and pericellular adipose tissue fibrosis.
They used the system to score preoperative subcutaneous adipose tissue biopsies from severely obese patients who underwent RYGB (N=183) and then tested the link between the score and poor response to the surgery (<28% total weight loss at 1 y), using univariate and multivariate models.
Funding: Assistance Publique-Hôpitaux de Paris; Fondation pour la Recherche Medicale.