Scoring system predicts weight loss after gastric bypass

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  • A new scoring system based on adipose tissue fibrosis can identify patients with poor potential for weight loss after Roux-en-Y gastric bypass (RYGB).

Why this matters

  • Many, but not all, patients experience major, sustainable weight loss after bariatric surgery; the ability to predict poor responders would improve postoperative patient follow-up.

Study design

  • Researchers created a semiquantitative scoring system based on both perilobular and pericellular adipose tissue fibrosis.
  • They used the system to score preoperative subcutaneous adipose tissue biopsies from severely obese patients who underwent RYGB (N=183) and then tested the link between the score and poor response to the surgery (<28% total weight loss at 1 y), using univariate and multivariate models.
  • Funding: Assistance Publique-Hôpitaux de Paris; Fondation pour la Recherche Medicale.