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SSRIs improve poststroke recovery according to a systematic review and meta-analysis

Susan London | Clinical Summary | 06 July 2022

Treatment netted better mental health, motor, and cognitive outcomes, although it did not reduce disability and did increase seizure risk.

Takeaway

A new meta-analysis finds that treating patients with selective serotonin reuptake inhibitors (SSRIs) after stroke improves most measures of recovery.

Why this matters

A 2018 Cochrane meta-analysis found little benefit of SSRIs.

Key results

Benefits of SSRIs vs placebo:
- Preventing depression (weighted mean difference [WMD], −7.05; 95% CI, −11.78...

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