Stroke risk after carotid endarterectomy reduced by dual antiplatelet therapy

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  • Dual antiplatelet therapy (aspirin and clopidogrel) is associated with reduced risk of stroke in patients undergoing carotid endarterectomy (CEA).

Study design

  • 28,683 patients undergoing CEA -- 75% receiving aspirin alone and 25% receiving dual therapy -- were analyzed for stroke and complication risk.
  • Propensity score-matched cohorts of 4548 patients were derived to control for subgroup heterogeneity.

Key results

  • Patients on dual therapy had significant reduced risk of stroke in multivariable analysis ...