The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts.

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  • OPN overexpression correlated with poor survival in NSCLC, and it might be a predictor of NSCLC invasion, metastasis, and prognosis.

Study Design

  • Meta-analysis of 13 studies that explored the relationship between the OPN elevation and the overall survival and disease-free survival  in NSCLC.
  • The cohort studies involved 1,630 patients.

Key Results

  • OPN was significantly associated with poor overall survival (HR =2.20, 95% CI 1.71-2.83, P<0.001) and disease free survival (HR =2.11, 95% CI 1.62-2.74, P<0.001) in NSCLC patients.
  • Overexpression tended to be associated with the presence of advanced tumor TNM stage (III and IV) (OR =2.57, 95% CI 1.61-4.11, P<0.001).
  • The Egger's test suggested that there was no publication bias.
  • Po...