The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts.
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- OPN overexpression correlated with poor survival in NSCLC, and it might be a predictor of NSCLC invasion, metastasis, and prognosis.
- Meta-analysis of 13 studies that explored the relationship between the OPN elevation and the overall survival and disease-free survival in NSCLC.
- The cohort studies involved 1,630 patients.
- OPN was significantly associated with poor overall survival (HR =2.20, 95% CI 1.71-2.83, P<0.001) and disease free survival (HR =2.11, 95% CI 1.62-2.74, P<0.001) in NSCLC patients.
- Overexpression tended to be associated with the presence of advanced tumor TNM stage (III and IV) (OR =2.57, 95% CI 1.61-4.11, P<0.001).
- The Egger's test suggested that there was no publication bias.