The Prognostic Significance of Midkine Overexpression in Breast Cancer

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  • Overexpression of tumor marker midkine was an unfavorable prognostic indicator of survival in breast cancer patients.

Study Design
  • The relationship between midkine protein overexpression and clinical characteristics, including survival, was assessed in 170 breast cancer patients.
  • Midkine protein expression was assayed by immunohistochemistry.
  • Midkine mRNA was assayed by real-time PCR.
  • Midkine DNA was assayed by Gene Expression Omnibus (GEO accession number: GDS3853)

Key Results
  • Midkine DNA was up-expressed i...