Ulcerative colitis: how should patients with low-grade dysplasia be managed?
Access to the full content of this site is available only to registered healthcare professionals.
Register to read more
For patients with ulcerative colitis with low-grade dysplasia (UC-LGD) under surveillance, annual incidence of progression to colorectal cancer (CRC) was low; high-risk features associated with dysplasia progression were primary sclerosing cholangitis, invisible dysplasia, distal location, and multifocal LGD.
Why this matters
Data on outcomes of patients with UC with LGD are limited.
In 14 surveillance cohort studies, 52 of 671 patients with UC-LGD developed CRC; pooled annual incidence for CRC was 0.8% and 1.8% for advanced neoplasia.
Risk for CRC was higher when LGD was diagnosed by gastrointestinal expert (1.5%) vs community pathologists (0.2%).
Dysplasia progression was significantly associated with concomitant primary sclerosing cholangitis, invisible vs visible...