Unmedicated psychosis: what predicts a good outcome?

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  • Among patients with first-episode psychosis who refused antipsychotic medication, remission was more likely in those with higher premorbid functioning levels, more education, and those who were employed.

Why this matters

  • More screening has led to earlier presentation of psychosis, often with less severe symptoms, which could open the door to other therapeutic options that do not have the potential side effects of antipsychotics.

Study design

  • The researchers studied an Australian cohort of 584 young people with first-episode psychosis.
  • Funding: Eli Lilly Australia and the FNS NCCR Funding Synapsy.

Key results

  • 17.9% of participants never took an adequate dose of antipsychotic m...