Vitamin D deficiency during pregnancy associated with preterm birth

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Takeaway

  • Vitamin D deficiency may be associated with increased risk for preterm labor.

Why this matters

  • Vitamin D deficiency during pregnancy has been linked to preeclampsia, gestational diabetes, intrauterine growth restriction, and impaired skeletal formation, but literature is conflicting.
  • Clinical recommendations for testing for and treating vitamin D deficiency are not available.
  • Vitamin D may play a role in immune modulation; may affect placentation and inflammation that can lead to preterm labor.

Key results

  • Vitamin D deficiency was associated with preterm birth (13% to 83% increased risk measured at <35 wk and <32-34 wk).
  • 4 studies provided evidence that decreasing vitamin D levels were associated with increased risk for preterm birth (relative risk [RR], 1.24...