Vitamin E not looking good to prevent dementia

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  • Vitamin E is not an effective treatment or prophylactic for Alzheimer's disease (AD) or mild cognitive impairment (MCI).

Why this matters

  • Any potential preventive treatment for dementia should be investigated in full because of the lack of effective treatments.
  • Low vitamin E levels are associated with a decline in cognitive function.
  • The authors discuss how vitamin E supplementation may also be harmful to health, even at low levels.

Study design

  • Meta-analysis of 2 double-blind, randomized trials (AD, n=304; MCI, n=516) evaluated the efficacy of vitamin E in patients with MCI or AD.
  • Funding: National Institute for Health Research.

Key results

  • No clinically significant effect of vitamin E in cognitive function (mean difference [MD], −1.81; P=.07) and neuropsychiatric symptoms (MD, ...