Weight gain, adiposity tied to esophageal, gastric cancers
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Overweight in early adulthood and weight gain later in life were associated with increased risks for esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA).
Why this matters
EA and GCA are increasing rapidly in the West, paralleled by increasing rates of obesity.
Overweight at age 20 y was associated with increased risk for EA (HR=1.76) and GCA (HR=1.62) vs BMI <25 kg/m2 at all points.
Being overweight (≥25-<30 kg/m2) at age 20 y and progressing to obesity (≥30 kg/m2) by age 50 y was also associated with increased risks for EA (HR=2.90) and GCA (HR=4.07), vs normal weight (≥18.5-<25 kg/m2) trajectory.
Weight gain ≥20 kg between age 20 y and baseline was associated with a 2-fold increased risk for EA (HR...