Weight gain, adiposity tied to esophageal, gastric cancers

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Takeaway

  • Overweight in early adulthood and weight gain later in life were associated with increased risks for esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA).

Why this matters

  • EA and GCA are increasing rapidly in the West, paralleled by increasing rates of obesity.

Key results

  • Overweight at age 20 y was associated with increased risk for EA (HR=1.76) and GCA (HR=1.62) vs BMI <25 kg/m2 at all points.
  • Being overweight (≥25-<30 kg/m2) at age 20 y and progressing to obesity (≥30 kg/m2) by age 50 y was also associated with increased risks for EA (HR=2.90) and GCA (HR=4.07), vs normal weight (≥18.5-<25 kg/m2) trajectory.
  • Weight gain ≥20 kg between age 20 y and baseline was associated with a 2-fold increased risk for EA (HR...