What happens when you cut PPI dosage by half?

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  • Halving proton pump inhibitor (PPI) dosage may be effective in patients with gastroesophageal reflux disease (GERD), particularly if they are female.

Why this matters

  • Prolonged exposure to PPIs is associated with osteoporosis, but stopping them entirely may lead to acid hypersecretion.
  • This study demonstrates that lowering the dosage may still effectively treat GERD, especially in female patients.

Key results

  • Median gastrin levels decreased from 71 to 53 pg/mL in the step-down group (P=.002) and increased from 52 to 56 pg/mL in the same-dose group (P=.04).
  • Female sex was associated with success in ste...