What is the risk of recurrence in patients with stage I colorectal cancer?

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  • Patients with stage I colorectal cancers still have a clinically significant risk of recurrence; rectal location is independently associated with higher recurrence, while age, elective surgery and American Society of Anesthesiologists (ASA) score are independently associated with recurrence-free survival.

Study design

  • This retrospective study evaluated outcomes in a contemporary series of 1193 patients with stage 1 colon or rectal adenocarcinoma who underwent resection with curative intent; median age was 67 (interquartile range 59-75) and median follow-up was 3.2 years (interquartile range 1.4-5.8).

Key results

  • The 5-year recurrence rate was 7.1% (95% confidence interval (CI) 5.4-9.4%; 5.0% for colon and 11.1% for rectal cancer).
  • Rectal loca...