Which antihypertensives are linked to decreased dementia risk in older patients?

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  • Calcium channel blockers (CCBs) are linked to reduced dementia risk in older patients, especially those without a history of cardiovascular disease (CVD).
  • Angiotensin receptor blockers (ARBs) also linked to reduced dementia risk in this population, but beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, and diuretics were not.

Why this matters  

  • Previous studies have suggested that ARBs and CCBs may be more protective against dementia than other antihypertensives, although 1 such study also found a benefit of loop diuretics.   
  • A Korean study found a protective benefit of CCBs against several types of dementia and a study in Taiwan found benefits of ACE inhibitors and ARBs in patients with type 2 diabetes.

Key results

  • Reduced dementia risk (adjusted HR; 95% CI) was associated with use of CCBs (0.56; 0.36-0.87) vs other antihypertensives, particularly in participants without a history of CVD (0.38; 0.18-0.81).
  • Reduced risk also observed with ARBs use (0.60; 0.37-0.98).
  • However, reduced risk not observed for beta...